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. 2006 Mar 13;172(6):817–822. doi: 10.1083/jcb.200506001

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Copyright © 2006, The Rockefeller University Press

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Figure 5. — Proposed molecular mechanism by which p66shc switches sos1 from a ras- to a rac1-specific GEF. Novel interaction required for the regulation of rac1 activity by p66shc is shown by dashed line.