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Deletion of Securin and one Separase allele is embryonic lethal
| Sec Δ/+ Sep +/+ | Sec Δ/+ Sep Δ/+ | Sec Δ/Δ Sep +/+ | Sec Δ/Δ Sep Δ/+ | Total | |
|---|---|---|---|---|---|
| SecΔ/Δ m × SecΔ/+SepΔ/+ f | |||||
| p10 | 9 | 7 | 13 | 0 | 29 |
| SecΔ/Δ f × SecΔ/+SepΔ/+ m | |||||
| p10 | 13 | 15 | 12 | 0 | 40 |
Securin Δ/Δ Separase +/+ and Securin Δ/+ Separase Δ/+ mice were intercrossed. No Securin Δ/Δ Separase Δ/+ mice were born in a total of 69 live births. m, male; f, female; p, postnatal day.
