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. 2006 Mar 27;172(7):983–990. doi: 10.1083/jcb.200508064

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Copyright © 2006, The Rockefeller University Press

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Figure 5. — Effect of UV irradiation on involucrin promoter-driven SCCA1 transgenic mice. (A) Immunostaining of SCCAs in wild-type and transgenic epidermis. Paraffin-embedded skin sections were stained with antibodies to SCCA1 or SCCA2. (B) Histological appearance of wild-type and transgenic mice 24 h after UV irradiation (200 mJ/cm²/d for 2 d). Wild-type (HR-1) mice demonstrated degeneration of the epidermis, including spongiosis (arrows) in the suprabasal layer. Involucrin-SCCA1 transgenic mice did not show any notable changes in UV-irradiated skin. Bars, 50 μm.