Table I.
Spatial redistribution of proteins in response to DSB-generating insults
| DSB-flanking chromatina |
ssDNA microcompartmentsb |
No retention at DSBsc |
|---|---|---|
| ATMd | ATRe | DNA-PKf |
| Nbs1e | ATRIPg | Ku70f |
| Mre11 | RPAg | Smc1f |
| Rad50 | Rad17 | Smc3e |
| Mdc1e g | Rad9 | Chk1e |
| 53BP1e g | Rad51g | Chk2e |
| BRCA1 | Rad52e | p53e g |
| BRCA2g | Cdc25A | |
| FANCD2 | ||
| Nbs1e | ||
| Mre11 | ||
| Rad50 | ||
| BRCA1 |
a
Interactions operating throughout the interphase.
b
S/G2-restricted interactions.
c
See text for further subclassification.
d
Interaction with the ssDNA microcompartments cannot be excluded.
e
Confirmed on the level of GFP.
f
Some retention could be observed in extremely dense DSB regions.
g
Confirmed by more than one antibody.