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. 2006 Apr 24;173(2):207–218. doi: 10.1083/jcb.200601105

Figure 7.

Figure 7.

Three-step model of human H/ACA RNP assembly. NAF1 associates with NAP57 in the cytoplasm (1). The complex is recruited to the site of H/ACA RNA transcription, as are NOP10 and NHP2 (2). GAR1 replaces NAF1 to yield mature H/ACA RNPs in nucleoli and Cajal bodies (3). Released NAF1 recycles across the nuclear envelope. NOP10 and NHP2 may already bind to NAP57 in the cytoplasm.