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Calpain and V-ATPase activity in necrotic cell death
| Strain | Corpses |
|---|---|
| mec-4(d) | 205 ± 9 |
| gfp(RNAi);mec-4(d) | 193 ± 11 |
| clp-1(RNAi);mec-4(d) | 96 ± 18 |
| vha-12(n2915)mec-4(d) | 112 ± 9 |
| gfp(RNAi);vha-12(n2915)mec-4(d) | 101 ± 13 |
| clp-1(RNAi);vha-12(n2915)mec-4(d) | 89 ± 16 |
Suppression of necrosis by calpain protease deficiency is not further enhanced by reduced vacuolar H+-ATPase activity. Values represent vacuolated touch receptor neurons (± SD) per 100 animals at the L1 stage. n > 250.
