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. 2006 May 22;173(4):485–495. doi: 10.1083/jcb.200512077

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Copyright © 2006, The Rockefeller University Press

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Figure 1. — Sycp3^−/− oocytes are rapidly and selectively lost after birth. Oocytes were detected in ovary sections by anti-GCNA1 (A–F) and anti–c-kit (G and H) immunohistochemistry (brown stain). At 1 dpp, both germ cell cysts (arrowhead) and primordial follicles were found in wild-type (A), as well as in Sycp3 ^−/− ovaries (B) in a similar number. The inset in B indicates germ cell cysts. (C) At 2 dpp, germ cell cysts (arrowhead) and primordial follicles were detected mostly in the periphery in wild-type. (D) A significant loss of germ cell cysts (arrowhead) and primordial follicles (inset) were observed in the Sycp3 ^−/− ovary at 2 dpp. At 4 dpp, both primordial follicles (arrowhead) and primary follicles were detected in wild type (E). A further loss of primordial follicles (arrowhead) was found in the Sycp3 ^−/− ovary (F), but no significant difference in the numbers of primary follicles (inset) was detected between wild type and mutant (F). (G and H) At 8 dpp, primordial (arrowheads), primary, and secondary follicles (inset) were detected in wild-type (G) and the Sycp3 ^−/− ovaries (H), but the number of primordial follicles was further reduced in the Sycp3 ^−/− ovary. Bars, 30 μm.