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Effect of GIT1 and PIX mutants on S273D-paxillin disassembly
| Expressed protein | t 1/2 (adhesion disassembly) |
|---|---|
| min | |
| S273D-pax | <1 |
| GIT1-ΔSHD + S273D-pax | 13.0 ± 0.8 |
| WT-GIT1+ S273D-pax | <1 |
| PIX-ΔGBD + S273D-pax | <1 |
| WT-PIX + S273D-pax | <1 |
| PIX-ΔSH3 + S273D-pax | 16.0 ± 1.1 |
| PIX-LL + S273D-pax | 14.4 ± 2.4 |
t 1/2 is reported as means ± SEM. For each t 1/2 determination, measurements were obtained for 15–20 individual adhesions on four to six cells from three independent experiments.
