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. 2006 May 22;173(4):601–613. doi: 10.1083/jcb.200508204

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Copyright © 2006, The Rockefeller University Press

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Figure 10. — Down-regulation of PI3-K activity is responsible for Sema4D/Plexin-B1–induced suppression of β₁ integrin activity. (A, left) Lysates of COS-7 cells expressing p110α-CAAX, a constitutively active form of PI3-K, or its kinase-dead (KD) form were immunoprecipitated with HUTS-4. (right) Relative β₁ integrin activity was analyzed. (B) Activity of β₁ integrins in COS-7 cells expressing the indicated expression plasmids with or without Sema4D stimulation were examined. (C and D) PC12 cells transfected with GFP alone (open symbols) or GFP plus p110α-CAAX (closed symbols) were tested in the transwell assay in either the presence or absence of Sema4D. Results are the means ± SEM of three independent experiments. Bar, 1 mm.