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. 2006 May 22;173(4):615–626. doi: 10.1083/jcb.200510161

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Copyright © 2006, The Rockefeller University Press

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Figure 7. — Models for the role of clathrin/AP-1 in the sorting of A(F→A)-ALP. (A) A(F→A)-ALP undergoes repeated rounds of cycling between the TGN and EE that involve sorting into clathrin/AP-1–coated vesicles at the EE. (B) Clathrin/AP-1 mediates the static retention of A(F→A)-ALP at the TGN. In both models, sorting is mediated by the interaction of AP-1 with residues 1–12 of A(F→A)-ALP. The GGA clathrin adaptors may participate with AP-1 in sorting A(F→A)-ALP.