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. 2006 Jun 5;173(5):659–664. doi: 10.1083/jcb.200510155

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Copyright © 2006, The Rockefeller University Press

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Figure 4. — IκBɛ mediates postinduction repression of NF-κB activity and inflammatory gene expression. (A) Nuclear NF-κB activity as predicted by computational modeling after 15 min of TNF stimulation. (B) EMSA of nuclear NF-κB activity in extracts prepared at the indicated time points from wild-type, iκbα^−/− , iκbα^−/− iκbɛ^−/−, and iκbɛ^−/− cells that were transiently stimulated for 15 min with 1 ng/ml TNF. (C) RPA reveals the mRNA levels over an extended time course of indicated NF-κB–responsive genes in wild-type, iκbα^−/−, and iκbα^−/− iκbɛ^−/− cells that were transiently stimulated for 45 min with TNF.