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. 2006 Jun 19;173(6):867–877. doi: 10.1083/jcb.200603153

Figure 3.

Figure 3.

Comparison of centrin N- and C-terminal domains and centrin binding sequences. (A) Comparison of N-terminal domains. Centrin A is green, B is yellow, C is red, D is blue, and E is gray. The bound Sfi1ps are in the corresponding colors, and centrin helices I–IV are marked. Also shown are the amino acids in the conserved position 10 of the Sfi1 repeat (Fig. 1), except for A285, which is at position 14 (Fig. 2 E). Here, because of the short repeat, centrin E binds to Sfi1p one turn of the helix later and binds to A285 in the same way as A682 and A255. (B) Comparison of C-terminal domains with notation as in A. Helices IV–VIII are marked, and the amino acids shown are in position 23 of the Sfi1 repeat. (C) Comparison of Sfi1p (red) and Kar1p (purple) bound to the C-terminal domains of yeast centrin A (green) and Chlamydomonas centrin (brown). Helices V–VIII are marked, together with amino acids L251 and W248 of Kar1p (Hu and Chazin, 2003) and F664 and W667 of Sfi1p.