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. 2006 Jun 19;173(6):867–877. doi: 10.1083/jcb.200603153

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Copyright © 2006, The Rockefeller University Press

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Figure 7. — Diagram of single and paired SPBs and a model for the initiation of SPB duplication. (A) Diagram of single and paired SPBs showing the location of half-bridge and bridge components. (B) A model of Sfi1p–centrin filaments associated side-by-side. Centrins have a 65° twist along Sfi1p and are shown as spheres or semispheres with filled and unfilled ovals as interaction patches, where filled patches interact with unfilled patches. Arrowheads show centrins interacting between filaments, assuming interactions occur within 15° of a total twist of 0° or 180°. (C) A model for the initial step in SPB duplication, viewed from above the SPB. We propose that the Sfi1p N terminus binds SPB components, whereas the C termini can associate end-to-end in an antiparallel way with or without other proteins. This provides a fresh Sfi1p N terminus capable of binding SPB components and thereby initiating SPB assembly.