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Model for the interactions between Nok/Mpp5 and Had/Na+,K+ ATPase in the maintenance of apical junction belts within myocardial cells. The ion pump activity of Had/Na+,K+ ATPase, which maintains the ionic balance of myocardial cells, interacts with the tight junction–associated protein Nok/Mpp5, a scaffolding partner of apical Crumbs and Par6–aPKCι protein complexes, in the stabilization of apical ZO-1–positive junctional belts.
