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. 2007 Jan 29;176(3):277–282. doi: 10.1083/jcb.200609021

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Copyright © 2007, The Rockefeller University Press

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Figure 5. — Inefficient radial sorting in mutant nerves is irreversible. (A) Light microscopy of 1-μm-thick transverse sections shows that wild-type sciatic nerves are extensively myelinated by 6 wk. (B) Light microscopy of mutant nerves reveals abundant bundles of unsorted axons, with some completely sorted axons (arrowhead) and some that have been partially sorted and myelinated at the periphery of bundles (arrow). (C) Electron microscopy shows that some of these bundles are enveloped by perineurial cells. (D) The bundles of large-caliber axons persist up to 6 mo after birth, with some evidence for further infiltration of perineurial fibroblasts (arrow). Bars: (A, B, and D) 5 μm; (C) 1 μm.