Table 3.
Medical record information based on a unique clinical event associated with a adenovirus-positive specimen for patients aged <7 years or patients who had received a transplant within 6 months prior to specimen collection (no duplicate isolates).
| Total no. of unique clinical events | Adenovirus hexon sequence genotype, no. (%) of unique clinical events |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Variable | 1 (n = 226) | 2 (n = 282) | 3 (n = 351) | 4 (n = 31) | 5 (n = 59) | 7 (n = 30) | 21 (n = 14) | 41 (n = 16) | Other (n = 50) | |
| Patient age group | ||||||||||
| <7 years | 1009 | 215 (21.3) | 275 (27.3) | 346 (34.3) | 29 (2.9) | 53 (5.3) | 29 (2.9) | 12 (1.2) | 15 (1.5) | 35 (3.5) |
| ≥7 years | 50 | 11 (22) | 7 (14) | 5 (10) | 2 (4) | 6 (12) | 1 (2) | 2 (4) | 1 (2) | 15 (30) |
| Patient sex | ||||||||||
| Male | 624 | 138 (22.1) | 170 (27.2) | 195 (31.3) | 21 (3.4) | 34 (5.4) | 16 (2.6) | 8 (1.3) | 7 (1.1) | 35 (5.6) |
| Female | 435 | 88 (20.2) | 112 (25.7) | 156 (35.9) | 10 (2.3) | 25 (5.7) | 14 (3.2) | 6 (1.4) | 9 (2.1) | 15 (3.4) |
| Immunocompromization | ||||||||||
| Cancer | 7 | 0 (0) | 4 (57.1) | 1 (14.3) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 1 (14.3) | 1 (14.3) |
| Cancer and transplantation | 38 | 5 (13.2) | 10 (26.3) | 5 (13.2) | 1 (2.6) | 1 (2.6) | 3 (7.9) | 1 (2.6) | 1 (2.6) | 11 (28.9) |
| Nothing reported | 936 | 203 (21.7) | 252 (26.9) | 332 (35.5) | 28 (3) | 48 (5.1) | 25 (2.7) | 12 (1.3) | 11 (1.2) | 25 (2.7) |
| Transplantation | 78 | 18 (23.1) | 16 (20.5) | 13 (16.7) | 2 (2.6) | 10 (12.8) | 2 (2.6) | 1 (1.3) | 3 (3.8) | 13 (16.7) |
| Upper respiratory tract infection | ||||||||||
| Yes | 450 | 109 (24.2) | 128 (28.4) | 154 (34.2) | 11 (2.4) | 27 (6) | 8 (1.8) | 4 (0.9) | 1 (0.2) | 8 (1.8) |
| Not reported | 609 | 117 (19.2) | 154 (25.3) | 197 (32.3) | 20 (3.3) | 32 (5.3) | 22 (3.6) | 10 (1.6) | 15 (2.5) | 42 (6.9) |
| Pneumonia | ||||||||||
| Yes | 98 | 16 (16.3) | 27 (27.6) | 35 (35.7) | 4 (4.1) | 5 (5.1) | 3 (3.1) | 2 (2) | 1 (1) | 5 (5.1) |
| Not reported | 961 | 210 (21.9) | 255 (26.5) | 316 (32.9) | 27 (2.8) | 54 (5.6) | 27 (2.8) | 12 (1.2) | 15 (1.6) | 45 (4.7) |
| Conjunctivitis | ||||||||||
| Yes | 70 | 7 (10) | 9 (12.9) | 41 (58.6) | 7 (10) | 3 (4.3) | 1 (1.4) | 0 (0) | 0 (0) | 2 (2.9) |
| Not reported | 989 | 219 (22.1) | 273 (27.6) | 310 (31.3) | 24 (2.4) | 56 (5.7) | 29 (2.9) | 14 (1.4) | 16 (1.6) | 48 (4.9) |
| Encephalitis | ||||||||||
| Yes | 4 | 1 (25) | 0 (0) | 2 (50) | 0 (0) | 0 (0) | 1 (25) | 0 (0) | 0 (0) | 0 (0) |
| Not reported | 1055 | 225 (21.3) | 282 (26.7) | 349 (33.1) | 31 (2.9) | 59 (5.6) | 29 (2.7) | 14 (1.3) | 16 (1.5) | 50 (4.7) |
| Duration of hospital stay | ||||||||||
| Not recorded | 32 | 4 (12.5) | 6 (18.8) | 18 (56.3) | 0 (0) | 3 (9.4) | 1 (3.1) | 0 (0) | 0 (0) | 0 (0) |
| No stay or unknowna | 460 | 111 (24.1) | 123 (26.7) | 164 (35.7) | 13 (2.8) | 17 (3.7) | 12 (2.6) | 2 (0.4) | 6 (1.3) | 12 (2.6) |
| up to 3 days | 300 | 74 (24.7) | 82 (27.3) | 103 (34.3) | 9 (3) | 13 (4.3) | 7 (2.3) | 3 (1) | 1 (0.3) | 8 (2.7) |
| 4-407 days | 255 | 35 (13.7) | 68 (26.7) | 63 (24.7) | 8 (3.1) | 26 (10.2) | 9 (3.5) | 9 (3.5) | 9 (3.5) | 28 (11) |
| Unknown no. of days | 12 | 2 (16.7) | 3 (25) | 3 (25) | 1 (8.3) | 0 (0) | 1 (8.3) | 0 (0) | 0 (0) | 2 (16.7) |
| Duration of intensive care unit stay | ||||||||||
| Not recorded | 3 | 1 (33.3) | 1 (33.3) | 1 (33.3) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) |
| No stay or unknowna | 973 | 209 (21.5) | 261 (26.8) | 331 (34) | 29 (3) | 48 (4.9) | 26 (2.7) | 8 (0.8) | 15 (1.5) | 46 (4.7) |
| 1-8 days | 39 | 9 (23.1) | 9 (23.1) | 9 (23.1) | 1 (2.6) | 6 (15.4) | 1 (2.6) | 2 (5.1) | 1 (2.6) | 1 (2.6) |
| 9-326 days | 39 | 7 (17.9) | 9 (23.1) | 7 (17.9) | 1 (2.6) | 5 (12.8) | 3 (7.7) | 4 (10.3) | 0 (0) | 3 (7.7) |
| Unknown no. of days | 5 | 0 (0) | 2 (40) | 3 (60) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) |
| Cause of death | ||||||||||
| Not recorded | 1 | 0 (0) | 0 (0) | 1 (100) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) |
| None or unknowna | 1046 | 225 (21.5) | 276 (26.4) | 350 (33.5) | 31 (3) | 58 (5.5) | 29 (2.8) | 12 (1.1) | 16 (1.5) | 49 (4.7) |
| Other unknown cause | 6 | 0 (0) | 3 (50) | 0 (0) | 0 (0) | 0 (0) | 1 (16.7) | 1 (16.7) | 0 (0) | 1 (16.7) |
| Primarily adenovirus infection | 6 | 1 (16.7) | 3 (50) | 0 (0) | 0 (0) | 1 (16.7) | 0 (0) | 1 (16.7) | 0 (0) | 0 (0) |
| Chronic disease | ||||||||||
| Not recorded | 31 | 6 (19.4) | 7 (22.6) | 14 (45.2) | 1 (3.2) | 1 (3.2) | 1 (3.2) | 0 (0) | 0 (0) | 1 (3.2) |
| No | 732 | 152 (20.8) | 201 (27.5) | 249 (34) | 22 (3) | 41 (5.6) | 21 (2.9) | 8 (1.1) | 8 (1.1) | 30 (4.1) |
| Yes | 208 | 49 (23.6) | 56 (26.9) | 49 (23.6) | 7 (3.4) | 11 (5.3) | 5 (2.4) | 6 (2.9) | 6 (2.9) | 19 (9.1) |
| Unknown | 88 | 19 (21.6) | 18 (20.5) | 39 (44.3) | 1 (1.1) | 6 (6.8) | 3 (3.4) | 0 (0) | 2 (2.3) | 0 (0) |
| No. of adenovirus-positive specimens per clinical eventb | ||||||||||
| 1 | 980 | 219 (22.3) | 263 (26.8) | 328 (33.5) | 26 (2.7) | 55 (5.6) | 23 (2.3) | 12 (1.2) | 13 (1.3) | 41 (4.2) |
| 2 | 44 | 4 (9.1) | 10 (22.7) | 16 (36.4) | 2 (4.5) | 3 (6.8) | 2 (4.5) | 2 (4.5) | 2 (4.5) | 3 (6.8) |
| 3 | 22 | 1 (4.5) | 5 (22.7) | 6 (27.3) | 3 (13.6) | 0 (0) | 2 (9.1) | 0 (0) | 0 (0) | 5 (22.7) |
| 4 | 1 | 0 (0) | 1 (100) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) |
| 5 | 4 | 0 (0) | 0 (0) | 1 (25) | 0 (0) | 1 (25) | 1 (25) | 0 (0) | 0 (0) | 1 (25) |
| 6 | 3 | 1 (33.3) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 1 (33.3) | 0 (0) | 1 (33.3) | 0 (0) |
| 7 | 2 | 1 (50) | 1 (50) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) |
| 9 | 2 | 0 (0) | 2 (100) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) |
| 20 | 1 | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 1 (100) | 0 (0) | 0 (0) | 0 (0) |
a
“Unknown” was a given response on the data forms.
b
No. of adenovirus-positive specimens per clinical event refers to the number of specimens submitted that were associated with a single clinical event for a unique patient on the basis of medical record review at the submitting laboratory.