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. 2007 Feb 26;176(5):709–718. doi: 10.1083/jcb.200610046

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Copyright © 2007, The Rockefeller University Press

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Figure 5. — Genetic interactions between Mek-dn and -sp transgenes and Runx2. TgMek-dn or -sp mice were crossed with Runx2+/− mice to generate the genotypes indicated. (a–d) Partial rescue of CCD phenotype in Runx2+/− mice with Mek-sp. (a) Skeletal whole mounts of newborn mice stained with alcian blue and alizarin red (top), isolated clavicles (middle), and crania (bottom). (b–d) measurements of femur length (b), clavicle areas (c), and mineralized area of calvaria (expressed as a fraction of total calvarial area). (e–h) Increased severity of CCD phenotype with Mek-dn. Groups are as in a–d. Statistical analysis values are expressed as the means ± the SD. n = 8 mice/group. Comparisons are indicated by bars. *, significantly different at P < 0.01.