Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2007 Mar 12;176(6):795–805. doi: 10.1083/jcb.200701066

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2007, The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

PMC Copyright notice

Figure 8. — Schematic depicting centromeric chromatin composition in relation to the cell cycle. CENP-A–containing nucleosomes (red) are interspersed with canonical H3-containing nucleosomes (green) after replication in S phase, and this mixed set of nucleosomes is the substrate for nucleating kinetochore assembly in mitosis and is maintained as cells exit in anaphase. CENP-A assembly initiates in telophase and proceeds through early G1 (presumably concurrent with removal of H3 nucleosomes). CENP-A– and H3-containing nucleosomes are stylized as single nucleosomes but may represent continuous alternating arrays of one or the other type. In mitosis, CENP-A nucleosomes may coalesce to form a rigid interface for kinetochore formation as proposed previously (Zinkowski et al., 1991; Blower et al., 2002; Black et al., 2004, 2007a,b).