Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2007 Apr 9;177(1):173–182. doi: 10.1083/jcb.200612116

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2007, The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

PMC Copyright notice

Figure 6. — Aberrant processing of profilaggrin. Equal amounts of protein extracts from wild-type (+/+), heterozygous (+/−), and homozygous mutant (−/−) epidermis were separated trough SDS-PAGE and subjected to Western blot analysis using specific antibodies against keratin 10 (K10), keratin 5 (K5), loricrin (Lor), β-actin (Act), filaggrin (Fil), and involucrin (Inv). Note the aberrant profilaggrin–filaggrin processing in the knockout epidermis with the complete loss of the filaggrin monomers and the accumulation of proteolytically derived intermediates (arrows).