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. 2006 Jul 3;174(1):27–38. doi: 10.1083/jcb.200603083

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Copyright © 2006, The Rockefeller University Press

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Figure 4. — Nonrandom spatial association between gene clusters. (A) 1.7 Mb separates the centers of two Mmu14 gene clusters (C1 and C2) and two deserts (D1 and D2). (B) C1 and C2 FISH signals (left, green and red, respectively) and D1 and D2 (right, green and red, respectively) in NIH-3T3 nuclei. Bar, 0.5 μm. (C) Percentile ranking of 3D center–center distances between indicated clusters and deserts in 100 chromosomes. (D) Computational model of “random” chromosome territory organization in a mouse nucleus. Territories are color-coded and represented as a series of connected 1-Mb spheres, with positions randomized in simulations. Inset shows Mmu14 spheres (yellow) corresponding to the clusters and deserts under study. (E) Center–center distances between indicated clusters and deserts in 100 simulated Mmu14 chromosomes. P-values are from the KS test.