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. 2007 May 21;177(4):683–694. doi: 10.1083/jcb.200701006

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Copyright © 2007, The Rockefeller University Press

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Figure 4. — Cells lacking caveolin-1 show accelerated turnover of nascent adhesions at protruding areas. (a) Cells were transiently transfected with pEGFP-paxillin and plated on an Fn matrix, and turnover of newly forming adhesions in protruding areas was monitored by time-lapse video microscopy. Seven frames of two representative cells are shown. The lifetime of several adhesions was followed and pointed with colored arrowheads. Each color indicates a different adhesion. Bars, 20 μm. (b) The lifetimes of adhesions were determined in 16 WT cells (274 FAs), 15 Cav1^−/− MEFs (376 FAs), and 10 Cav1^−/− MEFs reconstituted with caveolin-1 (354 FAs). Values are means ± SEM. ^*, Statistically significant versus WT MEFs; ^#, statistically significant versus Cav1^−/− MEFs.