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. 2007 Jun 4;177(5):871–880. doi: 10.1083/jcb.200702080

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Copyright © 2007, The Rockefeller University Press

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Figure 8. — Role of integrins in the adhesion of erythroid progenitors. (A) Schematic diagram of recombinant fibronectin fusion proteins. The V fragment contains both the α₄β₁- and α₅β₁-binding sites, Vo contains only the α₅β₁-binding site, VRGD⁻ contains only the α₄β₁-binding site, and VoRGD⁻ contains neither integrin-binding site. (B) Characterization of the adhesion of sorted R1 + R2, R3, R4, and R5 cells to 10 μg/ml V, Vo, or VRGD substrates at an acceleration of ∼1,000 g. (C) α₄β₁ and α₅β₁ integrins mediate adhesion to different fibronectin domains. Adhesion of sorted R1 + R2 cells to 10 μg/ml recombinant fibronectin fragments Vo or VRGD⁻ with and without pretreatment with function-blocking antibodies to α₄ and α₅ integrins. Each bar represents the mean fraction of cells adherent in each of three replicate wells. In all cases, error bars are the SD. *, P ≤ 0.05; **, P ≤ 0.01.