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. 2006 Sep 11;174(6):815–825. doi: 10.1083/jcb.200604015

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Copyright © 2006, The Rockefeller University Press

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Figure 9. — Local activation of CRAC channels by STIM1 at ER–plasma membrane junctions. Store depletion causes STIM1 to accumulate in preexisting and newly formed regions of junctional ER, whereas Orai1 accumulates in apposed regions of the plasma membrane. CRAC channels open only in the close vicinity of the STIM1 puncta. The convergence of STIM1 and Orai1 at ER–plasma membrane junctions creates the elementary unit of SOCE.