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. 2006 Sep 11;174(6):863–875. doi: 10.1083/jcb.200603013

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Copyright © 2006, The Rockefeller University Press

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Figure 8. — Dynamics of WT and mutant fascins in living cells. (A) Fluorescence images of cells expressing both CFP-Tc-shRNA (left) and one of YFP-tagged fascins refractory to shRNA (right). Active S39A fascin mutant (S39A*) induces numerous filopodia and shows localization along their length, whereas inactive S39E fascin mutant (S39E*) fails to increase the frequency of filopodia even at high levels of expression and shows mostly diffuse localization throughout the cytoplasm with slight enrichment in occasional filopodia. Bar, 10 μm. (B) Filopodial dynamics of WT or mutant fascins. Asterisks mark specific filopodia over time. Time is shown in seconds.