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Hypoxic increase in cytosolic ROS generated from the Qo site of complex III inhibits hydroxylation of HIF-1α protein. Immunoblot analysis of whole cell lysates for hydroxylated HIF-1α protein from WT cybrids (A) and ΔCyt b cybrids (B) treated with 20 μM MG132 to stabilize HIF-1α protein preincubated with 1 μM MitoQ or 1 μM control compound TPMP for 4 h and then subjected to 21% O2 (N), 1.5% O2 (H), or 1 mM DMOG (D) for 4 h. Representative blot from three independent experiments.
