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. 2007 Jun 18;177(6):1091–1104. doi: 10.1083/jcb.200610071

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Copyright © 2007, The Rockefeller University Press

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Figure 9. — Illustration of YPP1-mediated protection against A30P. Sla1p, Sla2p, and End3p form complexes at the actin cortical patches. Ypp1p binds to A30P and mediates the encapsulation of A30P into vesicles, which then bud off the membrane and transit to the vacuole. Class E Vps proteins are required for protein sorting into lumenal vesicles. The Mon1p–Ccz1p complex facilitates vesicle–vacuole fusion. MVB, multivesicular body.