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. 2006 Sep 25;174(7):1009–1021. doi: 10.1083/jcb.200509155

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Copyright © 2006, The Rockefeller University Press

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Figure 2. — Electron microscopic analysis of HSV-1 entry. TEM (A–H) and SEM (I–J) were performed to analyze HSV-1 entry into cells. Unless otherwise stated, all the images were captured 30 min after infection. (A) Virions (arrows) either bound to a nectin-1-CHO cell surface or loaded in vesicles, bar 0.4 μm. (B) Engulfment of virions (arrow) by protrusions present on the surface of a nectin-1-CHO cell, bar 0.5 μm. (C) Vesicles in nectin-1-CHO cell containing enveloped virions (arrows), bar 0.4 μm. (D–F) CF with membrane protrusions in the vicinity of HSV-1 virions and some enveloped virions in vesicles (arrows), bar 2 μm. (G) Virions (arrows) attaching to a protrusions-less cell surface of a TM cell, bar 0.8 μm. (H) Virions bound and apparently fusing with the plasma membrane of a TM cell, bar 2 μm. (I) Plasma membrane protrusions (arrowheads) from nectin-1-CHO with attached virions (arrows), bar 1 μm. (J) Virions (arrows) attached to a nectin-1-CHO protrusion, bar 100 nm. (K) Determination of percentage of plasma membrane protrusions scored from sampled groups of 250 single cells or clusters (with 5–20 cells), ∼5 μm length of a protrusion and at least 5% of the cell surface covered with protrusions is scored positive.