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. 2007 Jul 2;178(1):85–92. doi: 10.1083/jcb.200703206

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Copyright © 2007, The Rockefeller University Press

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Figure 6. — A model for the temporal regulation of salivary gland cell death by sequential pulses of ecdysone. Ecdysone (20E)–induced CBP expression at the mid-L3 transition directs down-regulation of DIAP1 in larval salivary glands to a critical threshold level, establishing competence for cell death. Later, ecdysone-induced rpr and hid expression at pupation (12 h APF) eliminates the remaining DIAP1, allowing caspase activation and salivary gland destruction.