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. 2007 Jul 2;178(1):93–105. doi: 10.1083/jcb.200703099

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Copyright © 2007, The Rockefeller University Press

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Figure 8. — Oxaloacetate or pyruvate rescue glutamine-depleted cells from apoptosis but not from cell cycle arrest. (A and B) I^ER-MYC cells were incubated in the presence of OHT (MYC^ON) or ethanol (MYC^OFF) for 24 h and then in the indicated media for 18 h before measuring cell viability. An average of three (A) and two (B) independent experiments is presented. Error bars in A indicate SDs. (C) I^{ER-MYC–C9DN} cells were incubated with OHT for 24 h. Media was then changed to that containing 2 mM of the indicated supplements and incubated for 24 h in one experiment (filled bars) or 48 h in the second experiment (open bars) before counting the cells. The relative increase in cell number is shown. (D) I^{ER-MYC–C9DN} cells were treated either with ethanol or OHT and then incubated with or without glutamine for the indicated time before measuring the NADH to NAD⁺ ratio. Treatment with rotenon (Rot) was used as a positive control.