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. 2007 Jul 2;178(1):167–178. doi: 10.1083/jcb.200703021

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Copyright © 2007, The Rockefeller University Press

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Figure 4. — Distribution of α5 integrin and siRNA-mediated depletion of αv integrin in FN^RGE/RGE cells. (A) Distribution of α5 and FN fibrils on wild-type (+/+) and FN^RGE/RGE (RGE/RGE) cells cultured for 24 h on LM111-coated dishes in serum replacement medium. Note that α5 and FN colocalize in fibrillar adhesions (arrowheads) of wild-type cells, whereas α5 is diffusely distributed in FN^RGE/RGE cells. (B) Knockdown of αv integrin in FN^RGE/RGE cells by transduction with retrovirus carrying anti–αv siRNA (αv siRNA) or control siRNA (scr.-siRNA) expression cassettes. αv-depleted FN^RGE/RGE cells were cultured for 48, 72, and 96 h on glass chamber slides coated with LM111 and stained for FN-RGE. Bars, 15 μm.