Table I.
Classification of the cell lines used in this study based on tissue of origin, transformation status, and CB status upon UV-C irradiation
| Cell line | Cell type | Tissue of origin | p53 status | Transformation status | UV-C–induced coilin redistribution |
|---|---|---|---|---|---|
| WI-38 | fibroblast | lung | wild type | not transformed | ++ |
| HCT-116 | epithelial-like | colon carcinoma | wild type | transformed | ++ |
| HeLa | epithelial | cervix adenocarcinoma | mut | transformed (HPV) | ++ |
| COS-7 | epithelial-like | kidney (simian) | mut | transformed (SV 40) | ++ |
| MCF-7 | epithelial-like | breast adenocarcinoma | wild type | transformed | ++ |
| 293 | epithelial | kidney | wild type (delocalized) | transformed (adenovirus) | ++ |
| HaCaT | epithelial | skin | mut | transformed (spontaneously) | +++ |
| SAOS-2 | epithelial-like | osteogenic sarcoma | null | transformed | ++ |
| SW 480 | epithelial-like | colon carcinoma | mut | transformed | ++ |
++ indicates that >50% of the observed cells show CB fragmentation upon UV-C treatment. +++ indicates that >80% of the observed cells show the CB fragmentation phenotype.