Table I.
List of mRNAs that associate (or do not) with nuclear eIF4E
| Target RNA | Function/growth-promoting properties | Translationally sensitive to eIF4E | Data for interaction | |||
|---|---|---|---|---|---|---|
| RNAs associated with the nuclear fraction of eIF4E | ||||||
| Cyclin D1 (gi: 77628152) |
G1/S cell cycle progression (Liang and Slingerland, 2003) |
No (Rousseau et al., 1996) |
Fig. 1 A | |||
| Cyclin E1 (gi: 17318558) |
G1/S cell cycle progression (Liang and Slingerland, 2003) |
ND | Fig. 1 A | |||
| Cyclin A2 (gi: 16950653) |
S/G2/M cell cycle progression (Liang and Slingerland, 2003) |
ND | Fig. S1 | |||
| Cyclin B1 (gi: 34304372) |
G2/M cell cycle progression (Liang and Slingerland, 2003) |
Yes (Cao and Richter, 2002) |
Fig. S1 | |||
| ODC (gi: 4505488) |
Polyamine synthesis/tumor promoting (Pegg, 2006) |
Yes (Clemens and Bommer, 1999) |
Fig. 1 A | |||
| Pim-1 (gi: 31543400) |
S/T kinase (Bachmann and Moroy, 2005) |
Yes (Clemens and Bommer, 1999) |
Fig. 1 A | |||
| Mdm2 (gi: 46488903) |
Survival/apoptotic rescue (Liang and Slingerland, 2003) |
ND | Fig. S1 | |||
| c-Myc (gi: 71774082) |
Facilitates G1/S progression and transcriptionally up-regulates eIF4E (Liang and Slingerland, 2003; Schmidt, 2004) |
Yes (Clemens and Bommer, 1999) |
Fig. 1 A | |||
| Nibrin/NBS1 (gi: 67189763) |
DNA repair/Akt activation/promotes growth (Chen et al., 2005) |
ND | Fig. S1 | |||
| Fbox1 (gi: 16306583) |
Promotes cell cycle progression (Liang and Slingerland, 2003) |
ND | Fig. S1 | |||
| CGGbp1 (gi: 56550052) |
Influences FMR1 expression (Naumann et al., 2004) |
ND | Fig. S1 | |||
| P54nrb/NONO.1 (gi: 34932413) |
RNA-binding protein/promotes survival (Stier et al., 2005) |
ND | Fig. S1 | |||
| Selenoprotein S (gi: 45439347) |
Glucose-regulated ER protein (Gao et al., 2004) |
ND | Fig. S1 | |||
| RNAs not associated with the nuclear fraction of eIF4E | ||||||
| GAPDH (gi: 83641890) |
Housekeeping/apoptotic | No (Rousseau et al., 1996; Clemens and Bommer, 1999) |
Fig. 1 A | |||
| VEGF (gi: 71051577) |
Mitogen/angiogenesis/tumor invasion (Roy et al., 2006) |
Yes (Clemens and Bommer, 1999) |
Fig. S1 | |||
| p53 (gi: 8400737) |
Proapoptotic/reduces eIF4E transcription (Zhu et al., 2005) |
No (Clemens and Bommer, 1999) |
Fig. 1 A | |||
| β-Actin (gi: 5016088) |
Cytoskeletal | No (Rousseau et al., 1996) |
Fig. S1 | |||
| α-Tubulin (gi: 57013275) |
Cytoskeletal | No | Fig. S1 | |||
| eIF4E (gi: 54873625) |
Translation and mRNA export promotes growth and survival (Strudwick and Borden, 2002) |
No (Clemens and Bommer, 1999; Strudwick and Borden, 2002) |
Fig. 1 A | |||
| PML (gi: 67089161) |
Proapoptotic/G1 arrest (Borden, 2002) |
No (Strudwick and Borden, 2002) |
Fig. 1 A | |||
| α-Globin (gi: 14456711) |
Housekeeping | No | Fig. S1 | |||
| c-ebpa (gi: 28872793) |
Arrests proliferation (Wang et al., 2001) |
ND | Fig. S1 | |||