Table 2. The binding of each aminoglycoside to TAR-2′pyr(25).
Number of amines | Mean Kd (μM)a | Fold maximal increase of Iobs | |
---|---|---|---|
Neomycin B | 6 | 5.8 ± 1 | 3.0 |
Neomycin C | 6 | 8.2 ± 4 | 3.0 |
Paromomycin | 5 | 72 ± 20 | 5.2 |
Kanamycin B | 5 | 89 ± 10 | 4.0 |
Tobramycin | 5 | 43 ± 4 | 3.8 |
Kanamycin A | 4 | 107 ± 13 | 3.6 |
Ribostamycin | 4 | 355 ± 33 | 1.7 |
aTolerances indicate the standard deviation of at least three independent measurements.