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. 2006 Oct 23;175(2):271–281. doi: 10.1083/jcb.200606050

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Copyright © 2006, The Rockefeller University Press

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Figure 4. — Rab38 colocalizes with melanosomal proteins in peripheral melanosomes and in perinuclear vesicles. BL/6 melanocytes were transiently transfected with EGFP-Rab38 (EGFP-38; A and F). Cells were fixed, permeabilized, and labeled with antibodies to tyrosinase (B) or Tyrp1 (G), as indicated. (C and H) Merged fluorescent images; (D and I) corresponding phase-contrast images; (E and J) Fluorescent signals and phase contrast (blue) are merged. Panels show regions of cells that include perinuclear and peripheral areas, and insets represent the whole cell. (K–O) Labeled structures at the cell periphery are depicted at higher magnification; EGFP-Rab38 (K), pigment (L), Tyrp1 (N), and merged images (M and O) are shown. (P–W) Melanocytes were cotransfected with EGFP-Rab27a (P and T) and mRFP-Rab38 (Q and U). (R and V) Merged images; (S and W) phase contrast.