Figure 8.
Tyrosinase and Tyrp1 trafficking to the melanosome is blocked in Rab38/Rab32-deficient cells. Cht melanocytes transfected with either control or Rab32-specific siRNA oligos as in Fig. 7 were fixed, permeabilized, and immunolabeled for Tyrp1 and tyrosinase, as indicated. The corresponding brightfield images are shown in the top panels.