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. 2006 Oct 23;175(2):305–313. doi: 10.1083/jcb.200608009

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Copyright © 2006, The Rockefeller University Press

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Figure 4. — Slik activity inhibits Merlin function genetically. The phenotypic modification of an activated Merlin protein (Mer^1-600) by reduction in Slik function was analyzed. (A) A representative example of a male wild-type wing from flies carrying the apGAL4 driver, which is expressed in the dorsal surface of the wing. (B) A representative example of a wing in which activated Merlin (Mer^1-600) is expressed in the dorsal surface of the wing under the apGAL4 driver. There is a mean 15% decrease in wing area from the wild type. (C) Removal of one copy of slik¹ in the wings expressing Mer^1-600 produces a further reduction in wing area by a mean of 18% from the wild type. Thus, reduction of Slik function enhances the activated Merlin phenotype. Measurements in each panel represent the mean area of the wing (millimeters squared) for each genotype. For each combination, at least 10 wings were measured. Bar, 200 μm.