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. 2006 Oct 23;175(2):305–313. doi: 10.1083/jcb.200608009

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Copyright © 2006, The Rockefeller University Press

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Figure 6. — Schematic diagram of functional relationships between Slik, Merlin, Moesin, and the regulation of tissue integrity and proliferation in developing epithelia. As demonstrated in this study, Slik activity simultaneously promotes Moesin function and inhibits Merlin. Our previous results have shown that Moesin functions to negatively regulate Rho activity and promote epithelial integrity (Speck et al., 2003). Merlin functions to restrict proliferation in the same epithelia. Thus, the net result of Slik activity is to drive proliferation and simultaneously stabilize epithelial integrity.