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Antibody cross-linking restores integrin activation. Clustering induced by anti-CEA mAb J22 and anti-NCAM mAb 123C3, plus secondary anti–mouse antibodies, of ΔNCEA and NCB, respectively, leads to an increase in binding of Fn from the culture media by ΔNCEA- and NCB-expressing cells. A nonbinding antibody, D13, as well as cross-linking of NCAM, did not lead to such an increase. Values shown are the means ± the SD for a representative experiment (*, P < 0.005).
