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. 2007 Sep 24;178(7):1237–1249. doi: 10.1083/jcb.200702184

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Copyright © 2007, The Rockefeller University Press

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Figure 10. — The role of F-spondin in midline crossing. (A) F-spondin is expressed and secreted from the floor plate cells. F-spondin is subjected to proteolysis by serine proteases within the amino end of TSR5 and between TSR5 and 6 (arrows). A yet unidentified protease cleaves F-spondin between the spondin domain and TSR1 (arrow). (B) The reelin/spondin domain (Burstyn-Cohen et al., 1999) and the adhesive TSR5 and 6 bind to the ECM that underlies the floor plate. The TSR1-4 fragment binds to the apical floor plate cells via interaction with the LRP receptors ApoER2, megalin, and LRP4. (C) The cell surface–tethered TSR1-4 repels commissural axons and prevents their penetration into the floor plate cells. The adhesive TSRs provide an outgrowth supportive substrate for the commissural axons.