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. 2007 Sep 24;178(7):1265–1278. doi: 10.1083/jcb.200705021

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Copyright © 2007, The Rockefeller University Press

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Figure 1. — The EPEC effector EspF binds both SNX9 and N-WASP. (A) Schematic of EspF proline-rich repeat (PRR) domains from EPEC, EHEC 0157:H7, and Citrobacter rodentium. SNX9 (blue) and putative N-WASP (orange) binding sites are shown. (B) Clustal alignment comparing each PRR domains of EspF from EPEC (EP), EHEC 0157:H7 (EH), and Citrobacter rodentium (CR) to those of EspFu/TccP (EH). GenBank accession no. is listed. The SNX9 binding site is highlighted in blue; and putative N-WASP binding residues are shown in orange. (C) Schematic of SNX9 showing the Src homology-3 (SH3), p47 oxidase (PHOX), and Bin-Amphiphysin-RVS (BAR) domains. The cDNA clone (residues 1–111) that interacts with EspF is indicated. (D) Schematic of N-WASP showing the Enabled/VASP homology 1 (EVH1), the Cdc42/rac interactive binding (CRIB), the poly-proline (Proline), and the Verpolin/Cofilin/Acidic (VCA) domain. The cDNA clone (residues 200–258) that interacts with EspF is indicated.