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. 2007 Sep 24;178(7):1279–1293. doi: 10.1083/jcb.200612053

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Copyright © 2007, The Rockefeller University Press

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Figure 3. — SGEF and RhoG-Q61L colocalized with ICAM1. (A) COS7 cells were transiently cotransfected with ICAM1-GFP (a and g) or ICAM1-V5 (d) and with GFP–RhoG-Q61L (e) or myc-SGEF (h). Image b shows F-actin. Images c, f, and i represent the merge. ICAM1 colocalizes with RhoG-Q61L and SGEF. Moreover, RhoG-Q61L and SGEF induce a change in ICAM1 distribution from spikes (a) to ruffles (arrowheads; d and g). (B) COS7 cells were transiently cotransfected with ICAM1-GFP (a and d), myc-SGEF (b), or myc-RhoG-Q61L (e). Panels c and f show merged images. Confocal x-z section images show colocalization between ICAM1 and SGEF (a–c) and ICAM1 and RhoG-Q61L (d–f) in dorsal membrane ruffles (arrowheads). Bars (A), 20 μm; (B) 10 μm.