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. 2006 Dec 4;175(5):709–714. doi: 10.1083/jcb.200608035

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Copyright © 2006, The Rockefeller University Press

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Figure 5. — Model integrating calcium mobilization into the Fas signaling pathway. Fas receptor stimulation causes rapid formation of the DISC complex, minimally comprising Fas-associated death domain protein (FADD) and initiator caspases 8/10. Our results suggest a rapid activation of PLC-γ1, leading to IP₃ generation and calcium release from IP₃R channels (indicated in red). Calcium release from IP₃R stores combined with increased mitochondrial permeability further amplify cytochrome c release. A temporally distinct chronic elevation of cytoplasmic calcium also occurs over the course of hours, mediated by cytochrome c binding to IP₃R.