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. 2006 Dec 4;175(5):715–720. doi: 10.1083/jcb.200606113

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Copyright © 2006, The Rockefeller University Press

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Figure 5. — Model of Did2 function in MVB sorting. The Did2 C terminus interacts with Vps4, and its N terminus interacts with the ESCRT-III subunit Vps24. Did2 is required for the endosomal dissociation of ESCRT-III and downstream components, which are Did2-dependent Vps4 substrates (green). ESCRT-I and -II (orange) are Did2-independent Vps4 substrates.