Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2006 Dec 18;175(6):913–923. doi: 10.1083/jcb.200512100

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2006, The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

PMC Copyright notice

Figure 2. — Comparison of parental HL-60 and Raji cells with the ρ^- clones for their apoptotic response to anticancer agents. (A) Quantitative analysis of apoptosis induced by 1 μg/ml As₂O₃ and 0.1 μM taxol for 24 h in parental HL-60 cells (Par) and respiration-deficient ρ^- cells (HL60-C6F). Apoptosis was assayed by annexin-V/PI staining and quantitated by flow cytometry analysis (n = 4 separate assays). The respiration-deficient HL60-C6F cells were significantly less sensitive to anticancer agents than the parental cells (*, P < 0.05 compared with the parental HL-60 cells). (B–D) Comparison of parental Raji cells with four respiration-deficient ρ^- cells for their apoptotic response to 1 μg/ml As₂O₃ for 24 h (B; n = 7), 0.1 μM doxorubicin for 36 h (C; n = 5), and 5 ng/ml vincristine for 36 h (D; n = 5). Apoptosis was assayed by annexin-V/PI staining and quantitated by flow cytometry analysis. Results are expressed as the mean ± the SD (*, P < 0.05 compared with the parental Raji cells).