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. 2007 Oct 8;179(1):129–138. doi: 10.1083/jcb.200703184

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Copyright © 2007, The Rockefeller University Press

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Figure 3. — JAK1-siRNA induces the accelerated expression of MyoD and MEF2, promotes a faster down-regulation of Id1, and enhances MEF2-dependent gene transcription. (A and B) C2C12 cells were transfected with various siRNAs as indicated. 24 h after transfection, cells were induced to differentiate in DM for various times as indicated. WCEs were prepared and subjected to immunoblotting. (C and D) Duplicate C2C12 cells were cotransfected with the luciferase reporter constructs together with either siRNAs (C) or cDNAs (D) as indicated. Cells were induced to differentiate in DM for 12 h before harvest. WCEs were subjected to luciferase assays. Fold activation or change was calculated as described in Figs. 1 and 2. The results are presented as mean ± SD (error bars).