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. 2007 Oct 22;179(2):219–227. doi: 10.1083/jcb.200708135

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Copyright © 2007, The Rockefeller University Press

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Figure 3. — mib2 is not required to localize integrin signaling components to muscle attachments. Except when denoted “WT” (wild type), embryos shown are derived from homozygous mib2¹ mutant germ line clones and have the zygotic genotype of mib2¹/Df(2L)TW130. Embryos in A–D also carry P5053A-Gal4 and UAS-lacZ on the Df(2L)TW130 chromosome to highlight muscle 12 (VL1). (A) At stage 14–15, normal localization of α_PS2 integrin to the ends of muscle 12 near the attachment sites in the absence of mib2 activity. (B) At early stage 16, mostly normal localization of α_PS2 integrin during the early phase of muscle 12 detachment. (C) During late stage 16, no localization of α_PS2 integrin in muscle 12 syncytia (arrows) that begin to deteriorate. Small red cells in A–D correspond to longitudinal gut muscles. (D) Stage 16 control embryo, showing α_PS2 integrin localized to the attachment sites within muscle 12. (E and F) Stage 15 embryos without and with mib2 activity, showing normal localization of Talin to the attachment sites within the myosin-stained muscles (arrowheads). In E, a few ventral muscles that have detached show evenly distributed Talin (arrows). (G and H) Stage 16 embryos without and with mib2 activity, showing normal localization of ILK-GFP to the attachment sites (arrowheads) except where muscles have detached and were shrinking.