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. 2007 Oct 22;179(2):255–267. doi: 10.1083/jcb.200706015

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Copyright © 2007, The Rockefeller University Press

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Figure 6. — Bub1^−/H and Bub1^H/H mice are prone to spontaneous tumors. (A) Tumor-free survival curves of Bub1^+/+, Bub1^+/−, Bub1^H/H, and Bub1^−/H mice. The asterisks mark curves that are significantly different from wild-type using a logrank test (P < 0.0001). We note that the tumor-free survival of a small cohort of Bub1^+/H mice (n = 10) was similar to that of Bub1^+/+ mice (not depicted). Furthermore, the median tumor-free survival of Bub1^−/H mice was significantly shorter than that of Bub1^H/H mice (P < 0.01). (B) Spontaneous tumor incidence and tumor latency of Bub1^+/+, Bub1^+/−, Bub1^H/H, and Bub1^−/H mice. (C) Tumor spectrum of Bub1^+/+, Bub1^+/−, Bub1^H/H, and Bub1^−/H mice. Asterisks mark values that are significantly different from wild type using a Fisher exact Chi-square test. (D) An overt hepatocellular carcinoma is indicated by the dashed line. (D′) Hematoxylin and eosin stained well-differentiated hepatocellular carcinoma, showing a proliferation of mildly atypical hepatocytes with abundant vascular channels, a lack of normal portal tracts, and a nodular focus (arrowheads) with mildly thickened trabeculae. (E) Thymic lymphoma (dashed line). (F) Overt lung adenocarcinoma (dashed circle). (F′) Hematoxylin and eosin–stained low-power magnification of a typical lung adenocarcinoma (dashed circle).