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. 2007 Oct 22;179(2):277–290. doi: 10.1083/jcb.200704141

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Copyright © 2007, The Rockefeller University Press

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Figure 6. — Rescue of proliferative potential of epidermal stem cells ex vivo and of small body-size phenotype in late generation telomerase-reconstituted G3 Terc^+/−* mice. (A) Representative images of number and size of macroscopic colonies obtained from isolated keratinocytes of the indicated genotypes. Note more abundant and larger colonies in G3 Terc ^+/−* mice compared with G3 Terc ^−/− littermates. (B) Quantification of size and number of macroscopic colonies obtained from isolated keratinocytes of the indicated genotype purified from 2-d-old mice and cultured for 10 d on J2-3T3 mitomycin C–treated feeder fibroblasts. (C) Representative images of newborn (left) and 2-mo-old (right) mice of the indicated genotype. Note a small body size in G3 Terc ^−/− mice compared with wild-type controls and that this small body-size phenotype is largely rescued in telomerase-reconstituted G3 Terc ^+/−* mice. (D) Quantification of body weight in newborn (left) and 2-mo-old (right) mice of the indicated genotypes. Note significantly reduced body size in newborn G3 Terc ^−/− mice compared with both wild-type controls and telomerase-reconstituted G3 Terc ^+/−* mice (P < 0.001 for both) and the significantly reduced body size in adult G3 Terc ^−/− mice compared with telomerase-reconstituted G3 Terc ^+/−* mice (P < 0.001). Error bars in B and D represent SEM.