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. 2007 Oct 22;179(2):277–290. doi: 10.1083/jcb.200704141

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Copyright © 2007, The Rockefeller University Press

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Figure 7. — Rescue of organismal life span in late generation telomerase-reconstituted G3 Terc^+/−* mice. (A) Kaplan-Meyer survival curve of mice of the indicated genotype. n is the number of mice of each genotype. Statistical comparisons using the log rank test are also shown. Note the significant rescue in survival of telomerase-reconstituted G3 Terc ^+/−* mice compared with G3 Terc ^−/− mice (P < 0.001). (B) Median survival obtained from Kaplan-Meyer plots of mice of the indicated genotypes. Statistical comparisons using the log rank test are also shown. Note the significantly reduced median survival of G3 Terc ^−/− mice compared with the other genotypes (P < 0.001). (C) Maximal lifespan of mice of the indicated genotypes. Note the decreased maximal life span of G3 Terc ^−/− mice and how this is corrected in telomerase-reconstituted G3 Terc ^+/−* mice. (D) Percentage of mice of the indicated genotype showing malignant tumors (lymphoma, histiocytic sarcoma, or sarcoma/carcinoma) at the time of death. Statistical comparisons using the χ² test are also shown. Note the decreased incidence of malignant tumors in G3 and G4 Terc ^−/− mice in agreement with a tumor-suppressor role associated with telomerase deficiency and short telomeres. Telomerase-reconstituted G4 Terc ^+/−* mice show a similar tumor incidence to that of wild-type controls. (E) Percentage of mice of the indicated genotype showing degenerative pathologies (atrophies) in the indicated tissues at the time of death. Statistical comparisons using the χ² test are also shown. Note the decreased incidence of intestinal atrophies in telomerase-reconstituted G4 Terc ^+/−* mice compared with G3 and G4 Terc ^−/− mice.