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Types of cancer-specific splicing shifts. (A) The relative proportions of LOD3 cancer-specific splicing that constituted a complete shift from one splice form in normal to another form in tumors (Switch); increase in one splice form in tumors (Gain); or loss of one form in tumors (Loss). (B) The same proportions, measured in genes for which the cancer-specific splice form was previously known; (C) in genes for which the cancer- specific form is novel.
